تحضير ، تشخيص طيفي ، دراسة التراكيب لمعقدات ايونات البلاتين +4 و الذهب +3 النانوية مع ليكاند قاعدة مانخ و تقييم نشاطها كمضادات للاكسدة
DOI:
https://doi.org/10.21123/bsj.2024.8552الكلمات المفتاحية:
مضادات الاكسدة ، سيبروفلوكساسين ،جذور حرة ، معقدات قاعدة مانخ ، حجم نانويالملخص
في هذا البحث تم تحضير المركبات المعدنية النانوية الجديدة لأيونات البلاتين 4+و الذهب 3+ مع ليكاند قاعدة مانخ جديد مشتق من السيبروفلوكساسين بطريقة الموجات فوق الصوتية. تم تشخيص المعقدات النانوية والليكاند الجديد بأستخدام تقنيات فيزيائية و كيميائية مختلفة مثل أطياف الاشعة تحت الحمراء، حيود الاشعة السينية ، المجهر الالكتروني الماسح ، المجهر الالكتروني النافذ و مجهر القوة الذرية. تم تحديد نشاط مضادات الأكسدة لدى لليكاند و معقداته النانوية.اظهرت النتائج أن المعقدات النانوية واعدة أكثر بأن تستخدم كمضادات للاكسدة في المستقبل خاصة عند التراكيز العالية
Received 08/02/2023,
Revised 20/06/2023,
Accepted 22/06/2023,
Published Online First 20/03/2024
المراجع
Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine, 4th ed.; Halliwell, B., Gutteridge, J.M.C., Eds.; Oxford University Press: New York, NY, USA, 2007. https://doi.org/10.1093/acprof:oso/9780198717478.001.0001.
Tena N, Martín J, Asuero A G. State of the art of anthocyanins: Antioxidant activity, sources, bioavailability, and therapeutic effect in human health. Antioxidants. 2020; 9(5): 451. https://doi.org/10.3390/antiox9050451.
Onwudiwe D C, Ekennia A C. Synthesis, characterization, thermal, antimicrobial and antioxidant studies of some transition metal dithiocarbamates. Res Chem Intermed .2017; 43(3): 1465-1485. https://doi.org/10.1007/s11164-016-2709-2.
4.Joshi S, Bilgaiyan P, Pathak A. Synthesis, spectroscopic characterization and antibacterial screening of novel Mannich bases of Ganciclovir. Arab J Chem. 2017; 10: 1180-1187. S1180-S1187. https://doi.org/10.1016/j.arabjc.2013.02.013.
Kerru N, Gummidi L, Maddila S, Gangu K K, Jonnalagadda SBA. review on recent advances in nitrogen-containing molecules and their biological applications. Molecules. 2020; 25(8): 1909. https://doi:10.3390/molecules25081909.
Ebenezer O, Jordaan M A, Carena G, Bono T, Shapi M, Tuszynski J A. An Overview of the Biological Evaluation of Selected Nitrogen-Containing Heterocycle Medicinal Chemistry Compounds. Int J Mol Sci. 2022; 23(15): 8117. https://doi.org/10.3390/ijms23158117.
Sankar A, Balakrishnan A . Aminomethylation, Structure and Biological activity of the new Mannich base and its Transition metal Complexes Derived from Isoindole-1, 3 (2H)–dione .Chem Sci Rev Lett. 2019; 8(29): 16-21. https://doi.org/10.24996/ijs.2022.63.12.1.
Abu-Dief A M, El-MetwalyN M, Alzahrani S O, Alkhatib F, Abualnaja M M, El-Dabea T, et al . Synthesis and characterization of Fe (III), Pd (II) and Cu (II)-thiazole complexes; DFT, pharmacophore modeling, in-vitro assay and DNA binding studies. J Mol Liq.2021; 326: 115277. https://doi.org/10.1016/j.molliq.2021.115277.
Abou-Melh KS, Al-Hazmi GA, Althagafi I, Alharbi A, Shaaban F, El-Metwaly NM, et al. Synthesis, characterization, DFT calculation, DNA binding and antimicrobial activities of metal complexes of dimedone arylhydrazone. J Mol Liq. 2021; 334: 116498. https://doi.org/10.1016/j.molliq.2021.116498.
Eftekhari A, Ahmadian E, Azami A, Johari-Ahar M, Eghbal MA. Protective effects of coenzyme q10 nanoparticles on dichlorvos-induced hepatotoxicity and mitochondrial/lysosomal injury. Environ Toxicol. 2018; 33: 167–177. https://doi.org/10.1002/tox.22505.
Pohlmann AR, Schaffazick SR, Creczynski-Pasa TB, Guterres SS. Preparation of drug-loaded polymeric nanoparticles and evaluation of the antioxidant activity against lipid peroxidation. In Free Radicals and Antioxidant . Methods Mol Biol. 2010; 610: 109–121. https://doi.org/10.1007/978-1-60327-029-8_7.
Feng L S, Liu M L, Zhang S, Chai Y, Wan B, Zhang Y B, et al. Synthesis and in vitro antimycobacterial activity of 8-OCH3 ciprofloxacin methylene and ethylene isatin derivatives. Eur. J. Med. Chem . 2011; 46(1): 341-348. https://doi.org/10.1016/j.ejmech.2010.11.023.
Öztürk İ, Beğiç N, Bener M, Apak R. Antioxidant capacity measurement based on κ-carrageenan stabilized and capped silver nanoparticles using green nanotechnology. J. Mol. Struct. 2021; 1242: 130846. https://doi.org/10.1016/j.molstruc.2021.130846.
Kumar J, Kumar N, Sati N, Hota P K. Antioxidant properties of ethenyl indole: DPPH assay and TDDFT studies. New J. Chem.2020;44(21):8960-8970. https://doi.org/10.1039/D0NJ01317J.
Abdulameer J H, Alias M F. Heavy Metal Complexes of 1, 2, 3-Triazole derivative: Synthesis, Characterization, and Cytotoxicity Appraisal Against Breast Cancer Cell Lines (MDA-MB-231). Baghdad Sci. J. 2022; 19(6): 1410-1422. https://doi.org/10.21123/bsj.2022.7178.
Mahmood Z N, Alias M, El-Hiti GAR, Ahmed DS, Yousif E. Synthesis and use of new porous metal complexes containing a fusidate moiety as gas storage media. Korean J. Chem. Eng. 2021;38: 179-186.https://doi.org/10.1007/s11814-020-0692-1.
Kowalczuk D, Gładysz A, Pitucha M, Kamiński D M, Barańska A, Drop B. Spectroscopic Study of the Molecular Structure of the New Hybrid with a Potential Two-Way Antibacterial Effect. Molecules. 2021;26(5): 1442. doi. https://doi.org/10.3390/molecules26051442.
Ali A, Chiang Y W, Santos R M. X-ray diffraction techniques for mineral characterization: A review for engineers of the fundamentals, applications, and research directions. Minerals. 2022; 12(2): 205. https://doi.org/10.3390/min12020205.
Baqer S R, Alsammarraie A M A, Alias M, Al-Halbosiy M M, Sadiq A S. In Vitro Cytotoxicity Study of Pt Nanoparticles Decorated TiO2 Nanotube Array. Cancer. 2020;17(4): 1169-1176. https://doi.org/10.21123/bsj.2020.17.4.1169
Podorov S G, Faleev N N, Pavlov K M, Paganin D M, Stepanov S A, Förster E. A new approach to wide-angle dynamical X-ray diffraction by deformed crystals. J. Appl. Crystallogr. 2006;39(5): 652-655.https://doi.org/10.1107/S0021889806025696.
Sagadevan S, Koteeswari P. Analysis of structure, surface morphology, optical and electrical properties of copper nanoparticles. J. Nanomed. Res., 2015;2(5): 00040-00048. https://doi.org/10.3390/nano10091812.
Lewczuk B, Szyryńska N. Field-emission scanning electron microscope as a tool for large-area and large-volume ultrastructural studies. Animals. 2021 ;11(12): 3390. https://doi.org/10.3390/ani11123390.
Higgins MR, Izadi A, Kaviani M. Antioxidants and exercise performance: with a focus on vitamin E and C supplementation. I J E R P H.2020; 17(22): 8452. https://doi.org/10.3390/ijerph17228452.
Baliyan S, Mukherjee R, Priyadarshini A, Vibhuti A, Gupta A, Pandey R P, et al. Determination of antioxidants by DPPH radical scavenging activity and quantitative phytochemical analysis of Ficus religiosa. Molecules.2022; 27(4): 1326. https://doi.org/10.3390/molecules27041326.
التنزيلات
إصدار
القسم
الرخصة
الحقوق الفكرية (c) 2024 Alya'a J. Ahmed, Mahasin F. Alias
هذا العمل مرخص بموجب Creative Commons Attribution 4.0 International License.
كيفية الاقتباس
