التخليق الأخضر للمتراكب النانوي: بناءً على [الأوجينول وأكاسيد المعادن], التشخيص والتطبيقات الطبية الحيوية
DOI:
https://doi.org/10.21123/bsj.2024.8324الكلمات المفتاحية:
الطب الحيوي, الأوجينول , التخليق الأخضر, اكاسيد المعادن, متراكب نانويالملخص
تم تفاعل الأوجينول (EUG) كمادة أساس مع خليط من أكاسيد المعادن (ZnO و CuO) التي تم تحضيرها من خلات المعدن، Zn (CH3CO2)2 و Cu (CH3CO2)2 كمواد أولية واستخدام الكلايكول إيثيلين (EG) كمذيب لتخليق المتراكب النانوي [Eug/ ZnO: CuO] باستخدام طريقة .Sol-Gel تم تشخيص المتراكب النانوي المحضر باستخدام التقنيات (FT-IR, AFM, SEM, EDX, و(XRD, حيث وجد أن متوسط قطر الجسيم يقع ضمن نطاق المقياس النانوي. ولوحظ أيضاً أن المادة النانوية المحضرة كانت على شكل قضبان ذات توزيع متجانس جيد. من أجل الوقوف على الخواص النانوية التي تم الحصول عليها، تم توظيف تلك الخواص من حيث البعد النانوي وخصائص الشكل، لدراسة فعالية المتراكب النانوي المحضر [Eug/ ZnO: CuO] كنشاط مضاد للميكروبات (مضاد للبكتيريا ومضاد للفطريات) ضد نوعين من البكتيريا [Escherichia Coli (-) (E. coli), and Staphylococcus aureus (+) (S. aureus)], ونوع واحد من الفطريات [Candida albicaus (C. albicaus)], حيث أظهرت نتائج مقبولة. كما تم قياس فعالية المتراكب النانوي المحضر كمضاد للأكسدة ضد الجذور الحرة وأظهر نسبة كسح جيدة. بالإضافة إلى ذلك تمت دراسة التأثير السمي الخلوي للمتراكب النانوي [Eug/ ZnO: CuO] على خلايا سرطان الثدي (MCF-7)، وأظهر نتائج مقبولة في قتل الخط الخلوي (MCF-7) بتراكيز عالية.
Received 04/01/2023
Revised 28/07/2023
Accepted 30/07/2023
Published Online First 20/02/2024
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