تقنية كرموتوغرافيا السائل ذات الاداء العالي ذوالطور العكسي مع كاشف الاشعة الفوق البنفسجية لتقدير ادوية الايبو بروفين والتنوكسيكام في الصورة النقية و الاقراص الدوائية

المؤلفون

DOI:

https://doi.org/10.21123/bsj.2024.8302

الكلمات المفتاحية:

الايبوبروفين ، التينوكسيكام ، تقنية كرموتوغرافيا السائل ذات الاداء العالي ذو الطور العكسي ، مكشاف الاشعة فوق البنفسجية ، منحيات المعايرة

الملخص

استخدمت تقنية  الكروماتوغرافيا السائل ذات الأداء العالي  ذات الطور العكسي مع كاشف الأشعة فوق البنفسجية حساس بدرجة كافية لقياس الكمية الضئيلة للدواء التنوكسيكام والايبو بروفين . في الدراسة الحالية ، تمت المعايرة بطريقة بسيطة وسريعة لتقدير الدوائين في عينات نقية وصيدلانية. تم فصل المواد التحليلية على عمود من الطور الساكن كاربون 18 ( 150 ملمتر في 4،6 ملمتر وقطر 5 مايكروميتر) . يشمل الطور المتحرك على الاسيتو نايتريل و الماء المحمض ( 0.7 مل من حامض الفسفوريك  في 1000 مل من الماء ) وسرعة  تدفق 1 مل بالدقيقة وحقن نموذج 20 مايكروليتر في درجة حرارة الغرفة .نتائج الفصل اجريت على المادة النقية اولا ثم على الاقراص الدوائية  لكلا الدوائين  ثم عمل منحني معايرة لكل مادة نقية باخذ 5 تراكيز . وتم التاكد من تميز الطريقة  وخطية العلاقة  من حيث الدقة والضبط  جيدة  وحد الكشف كان 1.5677 جزء جزء من المليون للتنوكسيكام  و 0.7911 جزء جزء من المليون لللايبوبروفين  للتركيزالمعين لكل دواء ونتائج هذه الطريقة كانت ملائمة  لتقدير كلا الدوائين في  كميات ضئيلة وبالصورة النقية والدوائية.  

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كيفية الاقتباس

1.
تقنية كرموتوغرافيا السائل ذات الاداء العالي ذوالطور العكسي مع كاشف الاشعة الفوق البنفسجية لتقدير ادوية الايبو بروفين والتنوكسيكام في الصورة النقية و الاقراص الدوائية . Baghdad Sci.J [انترنت]. [وثق 18 مايو، 2024];21(8). موجود في: https://www.bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8302