الهيبسيدين وبعض المتغيرات البيوكيميائية في الأطفال العراقيين الذين يعانون من نقص هرمون النمو

المؤلفون

  • Nawras Farhan Ali فرع الكيمياء التطبيقية، قسم العلوم التطبيقية، الجامعة التكنولوجية، بغداد، العراق
  • Wafaa R. Alfatlawi فرع الكيمياء التطبيقية، قسم العلوم التطبيقية، الجامعة التكنولوجية، بغداد، العراق
  • Abdulnasser M. Algebori فرع الكيمياء التطبيقية، قسم العلوم التطبيقية، الجامعة التكنولوجية، بغداد، العراق.
  • Noor Thair Tahir المركز الوطني للسكري والغدد الصماء، الجامعة المستنصرية، بغداد، العراق. https://orcid.org/0000-0001-9518-6634

DOI:

https://doi.org/10.21123/bsj.2023.8047

الكلمات المفتاحية:

نقص هرمون النمو, الهيبسيدين, عامل النمو الشبيه بالانسولين, الحديد, فيتامين د

الملخص

الهيبسدين هو بروتين يحافظ على توازن الحديد في الجسم . المعلومات حول دور الهيبسدين في الفسيولوجيا المرضية المرتبطة بنقص هرمون النمو (GHD) شحيحة. تهدف الدراسة إلى تقييم ودراسة ارتباط الهيبسدين ببعض المتغيرات الكيميائية الحيوية: هرمون النمو (GH) ، والعامل الشبيه بالأنسولين -1 (IGF-1) ، والحديد ، وفيتامين د ، والفوسفاتيز القلوي (ALP) ، والكالسيوم ، والفوسفور ، و الفيريتين في الأطفال الذين يعانون من نقص هرمون النمو.  الأطفال المشاركون في الدراسة والذين هم من المصابون بنقص هرمون النمو 60 والمتطوعون الأصحاء (60) في هذه الدراسة ، وتم جمع العينات  من المركز الوطني للسكري والغدد الصم - الجامعة المستنصرية من الفترة من يناير إلى أبريل 2022. تم استخدام فحص المواد الماصة المرتبطة بالإنزيم (ELIZA) لقياس Hep. و تم استخدام المقايسة المناعية الإشعاعية الكيميائية لقياس GH و IGF-1 ، وأظهرت النتائج انخفاضًا ملحوظًا p <0.01 في مستوى الهيبسيدين في مصل مرضى GHD مقارنة بالأفراد الأصحاء ، وزيادة مستويات الحديد ، وهذا يمكن أن يفسر العلاقة العكسية بين الهيبسيدين والحديد. وهو أهم منظم لامتصاص الحديد ، وهذه الآلية تتم من خلال التأثير الوقائي للالتهاب ضد فقر الدم عن طريق زيادة التوافر الحيوي لـ (Fe). لذلك فإن هذه الدراسة التي أجريت لإعطاء فهم أفضل للمعلمات التي تؤثر على الأطفال المصابين بـ GHD و Hep. يمكن أن تكون معلمة يمكن الاعتماد عليها لإدارة أفضل لهؤلاء الأطفال.

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1.
الهيبسيدين وبعض المتغيرات البيوكيميائية في الأطفال العراقيين الذين يعانون من نقص هرمون النمو. Baghdad Sci.J [انترنت]. [وثق 18 مايو، 2024];21(6). موجود في: https://www.bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8047